中文 | English
当前位置: 生物系

全院教师

生物系

生物系教师简介 —— 郭淑元 教授 / 博士生导师

来源:    发布日期:2018-09-04
 


郭淑元,理学博士,现为北京理工大学777威尼斯mg电子游戏教授,博士生导师,777威尼斯mg电子游戏教学督导组成员,生物工程系系主任。

1、联系方式
地址:北京理工大学777威尼斯mg电子游戏
邮编:100081
电话:68914495-803
传真:(010)-68915956
电子邮件:guosy @bit.edu.cn

2、教育背景
1988年9月-1992年7月,东北农业大学生物工程系获学士学位;
1992年9月-1995年7月,东北农业大学生物工程系获硕士学位;
2001年9月-2004年7月,清华大学生物科学与技术系,获博士学位。

3、工作简历
1995年7月-2001年8月,哈尔滨医科大学基础医学学院微生物学教研室教师;
2004年7月-今,历任北京理工大学777威尼斯mg电子游戏副教授、教授;
2008年6-12月,法国农业科学院,客作研究;
2010年9-11月,法国农业科学院,访问学者。

4、社会兼职
    2016年至今担任国际无脊椎动物病理学会细菌学分会理事 (the Society for Invertebrate Pathology, SIP, bacteria branch)。

5、研究领域/方向
    研究方向为微生物表达系统的改造、微生物与宿主的互作机理、生物活性蛋白的功能与应用开发等。
    参加国家科技部的973、863等相关项目,主持国家自然基金项目等。

6、招生专业
    博士研究生专业:生物医学工程(077700)
    学术型硕士生专业:①生物学专业(071000)微生物学/生物化学与分子生物学方向; ②化学工程与技术(081700)生物化工方向
    专业型硕士专业:生物工程(085238,专业学位)

7、代表性文章
1. Dongmei Feng, Zhen Chen, Zhiwen Wang, Chunlu Zhang, Kanglai He, Shuyuan Guo*. (2015) Domain III of Bacillus thuringiensis Cry1Ie Toxin Plays an Important Role in Binding to Peritrophic Membrane of Asian Corn Borer. PLOS ONE, 10(8): e0136430.
2. Yiling Zhan, Shuyuan Guo*. (2015) Three-dimensional (3D) structure prediction and function analysis of the chitin-binding domain 3 protein HD73_3189 from Bacillus thuringiensis HD73. Bio-Medical Materials and Engineering. 26: S2019–S2024.
3. Feng Li, Yue Yan, Dandan Wang, Jie Zhang, Shuyuan Guo*. (2014) Cry8Ca2-containing layer-by-layer microcapsules for the pH-controlled release of crystal protein. Journal of Microencapsulation. 31( 6) : 567-572.
4. Dandan Wang, Nan Zhang and Shuyuan Guo*. (2014) Structure and function analysis of protein HD73_0859 produced by Bacillus thuringiensis. Bio-Medical Materials and Engineering. 24: 3891–3896.
5. Shuyuan Guo*, Jie Li, Zhen Chen, Kanglai He. (2014)Penetration of a Single Domain of Bacillus thuringiensis Cry1Ie - Domain I to A Lipid Membrane in vitro. Journal of Integrative Agriculture. 13(5): 1043-1050.
6. Bingjie Ai, Jie Li, Dongmei Feng, Feng Li, Shuyuan Guo*. (2013) The elimination of DNA from the Cry toxin-DNA complex is a necessary step in the mode of action of the Cry8 toxin. PLOS ONE, 8(12): e81335.
7. Wenhui Yang, Kanglai He, Jie Zhang, Shuyuan Guo*. (2012) pH-Controlled Bacillus thuringiensis Cry1Ac Protoxin Loading and Release from Polyelectrolyte Microcapsules,PLOS ONE, 7(9), e45233.
8. Shuyuan Guo, Jie Li, Yanfeng Liu, Fuping Song, Jie Zhang. (2011) The role of DNA binding with the Cry8Ea1 toxin of Bacillus thuringiensis. FEMS Microbiology Letters, 317: 203-210.
9. Shuyuan Guo, Chunlu Zhang, Xiaoyin Lin, Yanrui Zhang, Kanglai He, Fuping Song, Jie Zhang. (2011) Purification of an active fragment of Cry1Ie toxin from Bacillus thuringiensis, Protein Express. Purif., 78(2): 204-208.
10. Xiaoai Wu, Sheng Ye, Shuyuan Guo, Wupeng Yan, Mark Bartlam, Zihe Rao. (2010) Structural basis for a reciprocating mechanism of negative cooperativity in dimeric phosphagen kinase activity. FASEB J. 24(1): 242-252.
11. Shuyuan Guo, Sheng Ye, Yanfeng Liu, Lei Wei, Jing Xue, Hongfu Wu, Fuping Song, Jie Zhang, Xiaoai Wu, Dafang Huang, Zihe Rao. (2009) Crystal Structure of Bacillus thuringiensis Cry8Ea1: An Insecticidal Toxin Toxic to Underground Pests, the Larvae of Holotrichia parallela, Journal of Structure Biology. 168: 259-266.
12. Shuyuan Guo, Yancai Zhang, Fuping Song, Jie Zhang, Dafang Huang. (2009) Protease-resistant core form of Bacillus thuringiensis Cry1Ie: monomer and oligomer formed in solution. Biotechnology Letter. 31: 1769-1774.
13. Guo Shu-Yuan, Wang Zheng, Ni Shao-Wei, Wang Xi-Cheng. (2003) Consequences of a six residual deletion from the N-terminal of rabbit muscle creatine kinase, Biochimie. 29 (10): 999-1005.
14. Guo Shu-Yuan,, Guo Zhi, Guo Qin, Chen Bao-Yu, Wang Xi-Cheng. (2003) Expression, purification and characterization of arginine kinase from the sea cucumber Stichopus japonicus, Protein Express. Purif. 29: 230-234.
15. Guo Shu-Yuan, Guo Zhi, Chen Bao-Yu, Guo Qin, Ni Shao-Wei, Wang Xi-Cheng. 7(2003) Urea induced inactivation and unfolding of arginine kinase from the sea cucumber stichopus japonicus. Biochemistry (Moscow), 68 (11): 1575-1580.
16. Zheng Yan-Bin, Guo Shu-Yuan, Guo Zhi, Wang Xi-Cheng. (2003) Effects of N-terminal Deletion Mutations on Rabbit Muscle Lactate Dehydrogenase. Biochemistry (Moscow), 69 (4): 401-406.
17. Guo Qin, Zhao Feng, Guo Shu-yuan, Wang Xi-Cheng. (2004) The tryptophan residues of dimeric arginine kinase: Roles of Trp-208 and Trp-218 in active site and conformation stability. Biochimie, 86:379-386.
18.郭淑元, 叶盛, 王政, 王希成, 刘一苇. 精氨酸激酶及其底物复合物的结晶和结晶学初步研究.(2004)自然科学进展,14(12): 1475-1478.
19.王政, 郭淑元, 张建伟, 王希成. (2005)点突变研究海参Stichopus japonicus精氨酸激酶的活性位点. 清华大学学报(自然科学版), 45(6):? 858-861.
20. 吴洪福, 张彦彩, 郭淑元*, 张杰, 王容燕, 高继国. (2007) 苏云金芽胞杆菌Cry8Ca2蛋白的纯化与活性的研究. 植物保护. 33(4):29-32.
21. 金有智, 郭淑元*. (2008) 昆虫对转Bt基因作物的抗性及对策.生命的化学. 28(3): 358-361.
22. 李峰,龚骞,严月,冯冬梅,郭淑元*. (2014) PH响应的层层自组装(LBL)微胶囊和多层薄膜研究, 化工新型材料. 10: 3-6.
23. 王丹丹, 郭淑元*. 芽胞杆菌肽聚糖水解酶的功能研究进展,生物技术通报, 2015, 31(2): 45-52.

8、授权专利
1. 专利名称:一种空微胶囊、可酸性或碱性控释的微胶囊及其制备方法,专利号:ZL201210257659.6,发明人:郭淑元,杨文慧,何康来,张杰,宋福平
2. 专利名称:苏云金芽胞杆菌原毒素微胶囊及其制备方法,专利号:ZL2013102870813,发明人:郭淑元,李峰,杨文慧

9、国际会议口头报告
1. International Congress on Invertebrate Pathology and Microbial Control & 44th Annual Meeting of the Society for Invertebrate Pathology,SIP 2011(加拿大,Saint Mary’s University),报告题目:Purification of an active fragment of Cry1Ie toxin from Bacillus thuringiensis
2. 15th International Biotechnology Symposium and Exhibition,IBS 2012(韩国,大邱),报告题目:pH-Controlled Bacillus thuringiensis Cry1Ac protoxin loading and release from Polyelectrolyte Microcapsule
3. he 46thAnnual Meeting of the Society for Invertebrate Pathology,SIP 2013(美国,匹兹堡),报告题目:A novel microcapsule formulation: alkaline releasing for Bacillus thuringiensis insecticidal proteins
4. 11th International Bhurban Conference on Applied Sciences and Technology, 2014(巴基斯坦,伊斯兰堡),报告题目:Structure and action mode of Cry toxins from Bacillus thuringiensis and its protection by microcapsule
5. the 47thAnnual Meeting of the Society for Invertebrate Pathology,SIP 2014 (德国,美因兹),报告题目:A necessary step in the mode of action of the Cry8 toxin: the elimination of DNA from the Cry toxin-DNA complex

10、研究生培养成绩
培养研究生获得国家奖学金:
1. 2012年11月,杨文慧
2. 2013年11月,李峰
3. 2014年12月,王丹丹

 

 

(审核:唐晓英)